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Beyond Compliance, Adherence, & Concordance – Supporting The Patient’s Implementation Of Optimal Treatment

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Check The Fine Print For Noncompliance – Part 1

August 4th, 2008 · Comments Off

Inadequate Font Size As A Cause Of Noncompliance

While young at heart, I am presbyopic of vision. Consequently, I have become aware of the difficulty reading certain types of texts that one routinely encounters on a frequent basis. The day to day category that has proved most troublesome is, by a wide margin, prescription medication labels.

It will surprise no one familiar with my interest in patient compliance that I have been speculating on the likelihood that misunderstanding and frustration engendered by problems reading the instructions jammed onto these labels lead to unintentional noncompliance with medication.

The potential for problems of this sort seems so high, in fact, that I have been surprised how infrequently this issue is listed as a possible cause. Illiteracy and instructions being written in a language other than the patient’s, for example, are much more common in the literature.

This week, I happened onto an exception to this pattern: Barriers to Medication Adherence in Poorly Controlled Diabetes Mellitus by Peggy Soule Odegard, PharmD and Shelly L. Gray, PharmD,1 identifies challenges to adherence behaviors in 77 patients taking diabetic medication. The pertinent results show that “taking more than two doses of DM medication daily and difficulty reading the DM medication prescription label were significantly associated with higher hemoglobin A1c.”2

The Variability and Quality of Medication Container Labels

Shrank and colleagues published The Variability and Quality of Medication Container Labels3, an assessment of “the format, content, and variability of prescription drug container labels dispensed in the community.”

Excerpted from the abstract:

Methods: Identically written prescriptions for 4 commonly used medications (atorvastatin calcium [Lipitor], alendronate sodium [Fosamax], trimethoprim-sulfamethoxazole [Bactrim], and ibuprofen) were filled in 6 pharmacies (the 2 largest chains, 2 grocery stores, and 2 independent pharmacies) in 4 cities (Boston, Chicago, Los Angeles, and Austin [Texas]). Characteristics of the format and content of the main container label and auxiliary stickers were evaluated. Labels were coded independently by 2 abstractors, and differences were reconciled by consensus.
Results: We evaluated 85 labels after excluding 11 ibuprofen prescriptions that were filled with over-the-counter containers that lacked labels printed at the pharmacy. The pharmacy name or logo was the most prominent item on 71 (84%) of the labels, with a mean font size of 13.6 point. Font sizes were smaller for medication instructions (9.3 point), medication name (8.9 point), and warning and instruction stickers (6.5 point). Color, boldfacing, and highlighting were most often used to identify the pharmacy and items most useful to pharmacists. While the content of the main label was generally consistent, there was substantial variability in the content of instruction and warning stickers from different pharmacies, and independent pharmacies were less likely to use such stickers (P less than .001). None of the ibuprofen containers were delivered with Food and Drug Administration–approved medication guides, as required by law.

To illustrate the results of materials printed font sizes, I have provided, in the graphic that follows, lines in Arial typeface in those same font sizes, rounded to the nearest whole number (which is given in parentheses).

Dr. Shrank’s findings are damning, and there is more, but that’s the next post.

Next
Small Print and Noncompliance – Part 2: More Evidence, Solutions, and Why This Issue Is Important (and not just to me)


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  1. Peggy Soule Odegard, PharmD and Shelly L. Gray, PharmD, Barriers to Medication Adherence in Poorly Controlled Diabetes Mellitus The Diabetes Educator, Vol. 34, No. 4, 692-697. 2008
  2. Increased A1c is used here as a proxy for poor adherence
  3. William H. Shrank, MSHS, MD; Jessica Agnew-Blais, et al. The Variability and Quality of Medication Container Labels. Arch Intern Med. 2007;167(16):1760-1765.

Tags: Public Health

The Tracey Ullman Patient Compliance Videos

April 15th, 2008 · Comments Off

Patient Education Goes Bollyhood

Once again, AlignMap takes patient education from the sad and drab ghetto of mainstream materials to the fab world of entertainment.

Check out Tracey Ullman’s conceptualization of patient counseling performed by the pharmacist.

Tags: Lay Media · Patient Education